KMID : 1001920170600020138
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Journal of Korean Neurosurgical Society 2017 Volume.60 No. 2 p.138 ~ p.145
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Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
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Lee Kyung-Jin
Shim In-Sop Sung Jae-Hoon Hong Jae-Taek Kim Il-Sup Cho Chul-Bum
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Abstract
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Objective: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson¡¯s disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is to investigate the effects of STN HFS in intact and 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rat model on changes of principal neurotransmitters, glutamate, and gamma-aminobutyric acid (GABA) in the striatum.
Methods: The authors examined extracellular glutamate and GABA change in the striatum on sham group, 6-OHDA group, and 6-OHDA plus deep brain stimulation (DBS) group using microdialysis methods.
Results: High-pressure liquid chromatography was used to quantify glutamate and GABA. The results show that HFS-STN induces a significant increase of extracellular glutamate and GABA in the striatum of 6-OHDA plus DBS group compared with sham and 6-OHDA group.
Conclusion: Therefore, the clinical results of STN-HFS are not restricted to the direct STN targets but involve widespread adaptive changes within the basal ganglia.
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KEYWORD
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Subthalamic nucleus , Glutamate , GABA , Deep brain stimulation , Parkinson disease
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